Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR...

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Pubblicato in:Sci Rep
Autori principali: Beaumont, Catherine, Walsh-Wilkinson, Élisabeth, Drolet, Marie-Claude, Roussel, Élise, Arsenault, Marie, Couet, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429715/
https://ncbi.nlm.nih.gov/pubmed/28389667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00855-9
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