Insights from engraftable immunodeficient mouse models of hyperinsulinaemia

Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 (−/−)) suitable for engraftment with human-derived tissue xenografts, an...

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Vydáno v:Sci Rep
Hlavní autoři: Maugham, Michelle L., Thomas, Patrick B., Crisp, Gabrielle J., Philp, Lisa K., Shah, Esha T., Herington, Adrian C., Chen, Chen, Gregory, Laura S., Nelson, Colleen C., Seim, Inge, Jeffery, Penny L., Chopin, Lisa K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428450/
https://ncbi.nlm.nih.gov/pubmed/28352127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00443-x
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