Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs.
Primary skin fibroblasts from hemophilic dogs were transduced by recombinant retrovirus (LNCdF9L) containing a canine factor IX cDNA. High levels of biologically active canine factor IX (1.0 micrograms per 10(6) cells per 24 hr) were secreted in the medium. The level of factor IX produced increased...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2367529/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5173 |
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