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Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs.

Primary skin fibroblasts from hemophilic dogs were transduced by recombinant retrovirus (LNCdF9L) containing a canine factor IX cDNA. High levels of biologically active canine factor IX (1.0 micrograms per 10(6) cells per 24 hr) were secreted in the medium. The level of factor IX produced increased...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Axelrod, J H, Read, M S, Brinkhous, K M, Verma, I M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54284/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2367529/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5173
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