Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

Chronic hepatitis C virus (HCV) infection is one of the major causes of serious liver diseases, including liver cirrhosis. There are no anti-fibrotic drugs with efficacy against liver cirrhosis. Wnt/β-catenin signaling has been implicated in the pathogenesis of a variety of tissue fibrosis. In the p...

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Udgivet i:Sci Rep
Main Authors: Tokunaga, Yuko, Osawa, Yosuke, Ohtsuki, Takahiro, Hayashi, Yukiko, Yamaji, Kenzaburo, Yamane, Daisuke, Hara, Mitsuko, Munekata, Keisuke, Tsukiyama-Kohara, Kyoko, Hishima, Tsunekazu, Kojima, Soichi, Kimura, Kiminori, Kohara, Michinori
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427997/
https://ncbi.nlm.nih.gov/pubmed/28336942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00282-w
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