The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts

Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength. Proper bone homeostasis and skeletal strength are maintained by balancing OC function with the bone-forming function of osteoblasts. Unfortuna...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kim, Hyunsoo, Walsh, Matthew C., Takegahara, Noriko, Middleton, Sarah A., Shin, Hong-In, Kim, Junhyong, Choi, Yongwon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427844/
https://ncbi.nlm.nih.gov/pubmed/28298636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00139-2
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