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The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts

Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength. Proper bone homeostasis and skeletal strength are maintained by balancing OC function with the bone-forming function of osteoblasts. Unfortuna...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kim, Hyunsoo, Walsh, Matthew C., Takegahara, Noriko, Middleton, Sarah A., Shin, Hong-In, Kim, Junhyong, Choi, Yongwon
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427844/
https://ncbi.nlm.nih.gov/pubmed/28298636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00139-2
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