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Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway
Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland, restored the impaired memory of aged mice. Age-r...
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| Pubblicato in: | EXCLI J |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Leibniz Research Centre for Working Environment and Human Factors
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5427465/ https://ncbi.nlm.nih.gov/pubmed/28507478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2016-852 |
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