High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions

P4-ATPases, also known as phospholipid flippases, are responsible for creating and maintaining transbilayer lipid asymmetry in eukaryotic cell membranes. Here, we use limited proteolysis to investigate the role of the N and C termini in ATP hydrolysis and auto-inhibition of the yeast flippase Drs2p-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Azouaoui, Hassina, Montigny, Cédric, Dieudonné, Thibaud, Champeil, Philippe, Jacquot, Aurore, Vázquez-Ibar, José Luis, Le Maréchal, Pierre, Ulstrup, Jakob, Ash, Miriam-Rose, Lyons, Joseph A., Nissen, Poul, Lenoir, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427273/
https://ncbi.nlm.nih.gov/pubmed/28302728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751487
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