Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module

Defects in mitochondrial cytochrome c oxidase or respiratory chain complex IV (CIV) assembly are a frequent cause of human mitochondrial disorders. Specifically, mutations in four conserved assembly factors impinging the biogenesis of the mitochondrion-encoded catalytic core subunit 2 (COX2) result...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Bourens, Myriam, Barrientos, Antoni
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427259/
https://ncbi.nlm.nih.gov/pubmed/28330871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778514
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