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The structure and function of Mycobacterium tuberculosis MazF-mt6 toxin provide insights into conserved features of MazF endonucleases

Toxin-antitoxin systems are ubiquitous in prokaryotic and archaeal genomes and regulate growth in response to stress. Escherichia coli contains at least 36 putative toxin-antitoxin gene pairs, and some pathogens such as Mycobacterium tuberculosis have over 90 toxin-antitoxin operons. E. coli MazF cl...

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Vydáno v:J Biol Chem
Hlavní autoři: Hoffer, Eric D., Miles, Stacey J., Dunham, Christine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427253/
https://ncbi.nlm.nih.gov/pubmed/28298445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.779306
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