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Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation of the total number of cellular receptors are believed to contribute t...

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Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Valiquette, M, Bonin, H, Hnatowich, M, Caron, M G, Lefkowitz, R J, Bouvier, M
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 1990
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54267/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2164220/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5089
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