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Selective N-terminal functionalization of native peptides and proteins
We report an efficient, highly selective modification on the N-terminal amines of peptides and proteins using aldehyde derivatives via reductive alkylation. After modification of a library of unprotected peptides XYSKEASAL (X varies over 20 natural amino acids) by benzaldehyde at room temperature, p...
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| Publicado en: | Chem Sci |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5426342/ https://ncbi.nlm.nih.gov/pubmed/28553506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc04744k |
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