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Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression

Targeting checkpoint inhibitors using monoclonal antibodies results in significantly better outcome of cancer patients compared to conventional chemotherapy. However, the current companion diagnostics to predict response is so far suboptimal, since they base on more or less reliable immunohistochemi...

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Detalles Bibliográficos
Publicado en:Clin Epigenetics
Main Authors: Marwitz, Sebastian, Scheufele, Swetlana, Perner, Sven, Reck, Martin, Ammerpohl, Ole, Goldmann, Torsten
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426039/
https://ncbi.nlm.nih.gov/pubmed/28503213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0354-2
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