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Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression

Targeting checkpoint inhibitors using monoclonal antibodies results in significantly better outcome of cancer patients compared to conventional chemotherapy. However, the current companion diagnostics to predict response is so far suboptimal, since they base on more or less reliable immunohistochemi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Epigenetics
Prif Awduron: Marwitz, Sebastian, Scheufele, Swetlana, Perner, Sven, Reck, Martin, Ammerpohl, Ole, Goldmann, Torsten
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426039/
https://ncbi.nlm.nih.gov/pubmed/28503213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0354-2
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