Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

To study the physiological roles of NADH and NADPH homeostasis in cancer, we studied the effect of NNT knockdown on physiology of SK-Hep1 cells. NNT knockdown cells show limited abilities to maintain NAD(+) and NADPH levels and have reduced proliferation and tumorigenicity. There is an increased dep...

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Detalles Bibliográficos
Publicado en:Redox Biol
Autores principales: Ho, Hung-Yao, Lin, Yu-Ting, Lin, Gigin, Wu, Pei-Ru, Cheng, Mei-Ling
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426036/
https://ncbi.nlm.nih.gov/pubmed/28478381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.04.035
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