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Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs

Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at diminishing this inflammatory response but have sig...

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Библиографические подробности
Опубликовано в: :Stem Cell Reports
Главные авторы: Brunger, Jonathan M., Zutshi, Ananya, Willard, Vincent P., Gersbach, Charles A., Guilak, Farshid
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425682/
https://ncbi.nlm.nih.gov/pubmed/28457885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.03.022
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