Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

Renal tubular epithelial cells are exposed to mechanical forces due to fluid flow shear stress within the lumen of the nephron. These cells respond by activation of mechano-sensors located at the plasma membrane or the primary cilium, having crucial roles in maintenance of cellular homeostasis and s...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Life Sci
Autori principali: Kunnen, Steven J., Leonhard, Wouter N., Semeins, Cor, Hawinkels, Lukas J. A. C., Poelma, Christian, ten Dijke, Peter, Bakker, Astrid, Hierck, Beerend P., Peters, Dorien J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425503/
https://ncbi.nlm.nih.gov/pubmed/28168444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2460-x
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