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Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase

Proteins obtain their final functional configuration through incremental folding with many intermediate steps in the folding pathway. If known, these intermediate steps could be valuable new targets for designing therapeutics and the sequence of events could elucidate the mechanism of refolding. How...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425382/
https://ncbi.nlm.nih.gov/pubmed/28494954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.03.028
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