Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells

To identify vascular disruptor compounds (VDCs), this study utilized an in vivo zebrafish embryo vascular model in conjunction with a mouse endothelial cell model to screen a subset of the U.S. Environmental Protection Agency (EPA) ToxCast Phase I chemical inventory. In zebrafish, 161 compounds were...

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Pubblicato in:Reprod Toxicol
Autori principali: McCollum, Catherine W., Vancells, Javier Conde, Hans, Charu, Vazquez-Chantada, Mercedes, Kleinstreuer, Nicole, Tal, Tamara, Knudsen, Thomas, Shah, Shishir S., Merchant, Fatima A., Finnell, Richard H., Gustafsson, Jan-Åke, Cabrera, Robert, Bondesson, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425326/
https://ncbi.nlm.nih.gov/pubmed/27838387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2016.11.005
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