BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5

Selection and maturation of B cells into plasma cells producing high-affinity antibodies occur in germinal centers (GC). GCs form transiently in secondary lymphoid organs upon antigen challenge, and the GC reaction is a highly regulated process. TGF-β is a potent negative regulator, but the influenc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bollum, Lise K., Huse, Kanutte, Oksvold, Morten P., Bai, Baoyan, Hilden, Vera I., Forfang, Lise, Yoon, Sun Ok, Wälchli, Sébastien, Smeland, Erlend B., Myklebust, June H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425193/
https://ncbi.nlm.nih.gov/pubmed/28489883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177188
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