Pharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis

PURPOSE: Emerging data on selumetinib, a MEK1/2 inhibitor in clinical development, suggest a possible difference in pharmacokinetics (PK) between Japanese and Western patients. This pooled analysis sought to assess the effect of ethnicity on selumetinib exposure in healthy Western and Asian subjects...

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Udgivet i:Eur J Clin Pharmacol
Main Authors: Dymond, Angela W., Elks, Cathy, Martin, Paul, Carlile, David J., Mariani, Gabriella, Lovick, Susan, Huang, Yifan, Lorch, Ulrike, Brown, Helen, So, Karen
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Pharmacokinetics and Disposition
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423974/
https://ncbi.nlm.nih.gov/pubmed/28283692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-017-2217-3
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