Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression

The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu(342)Lys) A1AT deficiency-related emphysema. Potential hepatic gains of this therapy are unknown. Herein, we investiga...

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Vydáno v:PLoS One
Hlavní autoři: Karadagi, Ahmad, Johansson, Helene, Zemack, Helen, Salipalli, Sandeep, Mörk, Lisa-Mari, Kannisto, Kristina, Jorns, Carl, Gramignoli, Roberto, Strom, Stephen, Stokkeland, Knut, Ericzon, Bo-Göran, Jonigk, Danny, Janciauskiene, Sabina, Nowak, Greg, Ellis, Ewa C. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423693/
https://ncbi.nlm.nih.gov/pubmed/28486562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177279
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