Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits and two identical or different non-GluN1 subunits that include six different ge...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Bledsoe, Douglas, Tamer, Ceyhun, Mesic, Ivana, Madry, Christian, Klein, Bradley G., Laube, Bodo, Costa, Blaise M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423295/
https://ncbi.nlm.nih.gov/pubmed/28536523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00229
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