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Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis

The tumor suppressor p53 plays a critical role in suppressing cancer growth and progression and is an attractive target for the development of new targeted therapies. We synthesized several indolo‐pyrido‐isoquinolin based alkaloids to activate p53 function and examined their therapeutic efficacy usi...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Avtanski, Dimiter B., Nagalingam, Arumugam, Tomaszewski, Joseph E., Risbood, Prabhakar, Difillippantonio, Michael J., Saxena, Neeraj K., Malhotra, Sanjay V., Sharma, Dipali
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423185/
https://ncbi.nlm.nih.gov/pubmed/27259808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.04.003
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