Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Pancreatic ductal adenocarcinoma (PDAC) clinically has a very poor prognosis. No small molecule is available to reliably achieve cures. Meisoindigo is chemically related to the natural product indirubin and showed substantial efficiency in clinical chemotherapy for CML in China. However, its effect...

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Detaylı Bibliyografya
Yayımlandı:Mol Oncol
Asıl Yazarlar: Cheng, Xinlai, Kim, Jee Young, Ghafoory, Shahrouz, Duvaci, Tijen, Rafiee, Roya, Theobald, Jannick, Alborzinia, Hamed, Holenya, Pavlo, Fredebohm, Johannes, Merz, Karl-Heinz, Mehrabi, Arianeb, Hafezi, Mohammadreza, Saffari, Arash, Eisenbrand, Gerhard, Hoheisel, Jörg D., Wölfl, Stefan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423166/
https://ncbi.nlm.nih.gov/pubmed/26887594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.01.008
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