Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice

The roles of D-serine in depression are raised concerned recently as an intrinsic co-agonist for the NMDA receptor. However, the mechanisms underlying its regulation are not fully elucidated. ASCT2 is a Na(+)-dependent D-serine transporter. We found that decreased D-serine and increased hippocampal...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Wang, Jiesi, Zhang, Ke, Chen, Xiaojuan, Liu, Xiaoqian, Teng, Huajing, Zhao, Mei, Sun, Zhongsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422558/
https://ncbi.nlm.nih.gov/pubmed/28536503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00139
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