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Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
Major depressive disorder (MDD) is associated with reduced concentrations of γ-aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover, depressive-like phenotypes of GABA(A) receptor mutant mice can be reversed by treatment with conventional antidepressants drugs, as well...
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| 出版年: | Mol Psychiatry |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5422144/ https://ncbi.nlm.nih.gov/pubmed/27821870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.188 |
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