Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody-drug conjugate

BACKGROUND: Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett’s epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. RESULTS: MUC1 was pr...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Butt, Mohammed Adil, Pye, Hayley, Haidry, Rehan J., Oukrif, Dahmane, Khan, Saif-U-Rehman, Puccio, Ignazio, Gandy, Michael, Reinert, Halla W., Bloom, Ellie, Rashid, Mohammed, Yahioglu, Gokhan, Deonarain, Mahendra P., Hamoudi, Rifat, Rodriguez-Justo, Manuel, Novelli, Marco R., Lovat, Laurence B.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421911/
https://ncbi.nlm.nih.gov/pubmed/28212575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15340
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