Activation of JNK and IRE1 is critically involved in tanshinone I-induced p62 dependent autophagy in malignant pleural mesothelioma cells: implication of p62 UBA domain

The aim of present study is to elucidate autophagic mechanism of tanshinone I (Tan I) in H28 and H2452 mesothelioma cells. Herein, Tan I exerted cytotoxicity with autophagic features of autophagy protein 5 (ATG5)/ microtubule-associated protein 1A/1B-light chain 3II (LC3 II) activation, p62/sequesto...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lee, Jihyun, Sohn, Eun Jung, Yoon, Sangwook, Won, Gunho, Kim, Chang Geun, Jung, Ji Hoon, Kim, Sung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421907/
https://ncbi.nlm.nih.gov/pubmed/28212571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15336
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