Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer

Tumor cell-derived hyaluronidase HYAL-1 degrades hyaluronic acid (HA) into angiogenic fragments (AGF: 10-12 disaccharides). AGF support tumor growth and progression. Urine and tissue HAase/HYAL-1 levels are sensitive markers for high-grade bladder cancer (BCa) and its metastasis. In preclinical mode...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jordan, Andre R., Lokeshwar, Soum D., Lopez, Luis E., Hennig, Martin, Chipollini, Juan, Yates, Travis, Hupe, Marie C., Merseburger, Axel S., Shiedlin, Aviva, Cerwinka, Wolfgang H., Liu, Kebin, Lokeshwar, Vinata B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421845/
https://ncbi.nlm.nih.gov/pubmed/27419371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10529
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