Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer

Tumor cell-derived hyaluronidase HYAL-1 degrades hyaluronic acid (HA) into angiogenic fragments (AGF: 10-12 disaccharides). AGF support tumor growth and progression. Urine and tissue HAase/HYAL-1 levels are sensitive markers for high-grade bladder cancer (BCa) and its metastasis. In preclinical mode...

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Foilsithe in:Oncotarget
Main Authors: Jordan, Andre R., Lokeshwar, Soum D., Lopez, Luis E., Hennig, Martin, Chipollini, Juan, Yates, Travis, Hupe, Marie C., Merseburger, Axel S., Shiedlin, Aviva, Cerwinka, Wolfgang H., Liu, Kebin, Lokeshwar, Vinata B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421845/
https://ncbi.nlm.nih.gov/pubmed/27419371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10529
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