Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity

We propose a model by which an increase in the genomic modification, 5-hydroxymethylcytosine (5hmC), contributes to B cell death within the chicken bursa of Fabricus (BF) infected with infectious bursal disease virus (IBDV). Our findings indicate that, following an IBDV infection, Rhode Island Red (...

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Detalhes bibliográficos
Publicado no:Dev Comp Immunol
Main Authors: Ciccone, Nick A., Smith, Lorraine P., Mwangi, William, Boyd, Amy, Broadbent, Andrew J., Smith, Adrian L., Nair, Venugopal
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421744/
https://ncbi.nlm.nih.gov/pubmed/28322935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dci.2017.03.014
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