Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

Telomeres are essential in maintaining chromosome integrity and in controlling cellular replication. Attrition of telomere length in peripheral blood mononuclear cells (PBMCs) with age is well documented from cross-sectional studies. But the actual in vivo changes in telomere lengths and its relatio...

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Veröffentlicht in:Clin Sci (Lond)
Hauptverfasser: Lin, Yun, Damjanovic, Amanda, Metter, E. Jeffrey, Nguyen, Huy, Truong, Thai, Najarro, Kevin, Morris, Christa, Longo, Dan L., Zhan, Ming, Ferrucci, Luigi, Hodes, Richard J., Weng, Nan-ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421624/
https://ncbi.nlm.nih.gov/pubmed/25317735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20140481
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