Room Temperature Housing Results in Premature Cancellous Bone Loss in Growing Female Mice: Implications for the Mouse as a Preclinical Model for Age-Related Bone Loss

PURPOSE: Female mice are often used as preclinical models for osteoporosis but, in contrast to humans, mice exhibit cancellous bone loss during growth. Mice are routinely housed at room temperature (18–23°C), a strategy that exaggerates physiological differences in thermoregulation between mice (obl...

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Detalhes bibliográficos
Publicado no:Osteoporos Int
Main Authors: Iwaniec, Urszula T., Philbrick, Kenneth A., Wong, Carmen P., Gordon, Jody L., Kahler-Quesada, Arianna M., Olson, Dawn A., Branscum, Adam J., Sargent, Jennifer L., DeMambro, Victoria E., Rosen, Clifford J., Turner, Russell T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421618/
https://ncbi.nlm.nih.gov/pubmed/27189604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00198-016-3634-3
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