Implications for Ophthalmic Formulations: Ocular Buffers Show Varied Cytotoxic Impact on Human Corneal–Limbal and Human Conjunctival Epithelial Cells

PURPOSE: To investigate toxicity associated with buffers commonly used in topical ocular drug formulations using a human corneal–limbal epithelial (HCLE) and a human conjunctival epithelial (HCjE) cell model. METHODS: HCLE and HCjE cells were incubated for 10, 30, or 60 minutes with 4 different buff...

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Bibliographic Details
Published in:Cornea
Main Authors: Schuerer, Nadine, Stein, Elisabeth, Inic-Kanada, Aleksandra, Pucher, Marion, Hohenadl, Christine, Bintner, Nora, Ghasemian, Ehsan, Montanaro, Jacqueline, Barisani-Asenbauer, Talin
Format: Artigo
Language:Inglês
Published: Cornea 2017
Subjects:
Basic Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421463/
https://ncbi.nlm.nih.gov/pubmed/28399036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ICO.0000000000001199
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