Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease

BACKGROUND: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in patients is due to the disease progression itself, or is affected by L-DOPA replacement...

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Detalhes bibliográficos
Publicado no:Chin Med J (Engl)
Main Authors: Li, Si-Yue, Wang, Ya-Li, Liu, Wen-Wen, Lyu, Dong-Jun, Wang, Fen, Mao, Cheng-Jie, Yang, Ya-Ping, Hu, Li-Fang, Liu, Chun-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421180/
https://ncbi.nlm.nih.gov/pubmed/28469105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0366-6999.204920
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