The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics

The neuropeptide vasoactive intestinal peptide (VIP) strongly impacts on human pathophysiology and does so through interaction with class II G protein-coupled receptors. We characterized the C terminus-binding site of VIP in the N-terminal ectodomain (N-ted) of the human VPAC1 receptor: 1) The probe...

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Publicat a:Mol Endocrinol
Autors principals: Ceraudo, Emilie, Murail, Samuel, Tan, Yossan-Var, Lacapère, Jean-Jacques, Neumann, Jean-Michel, Couvineau, Alain, Laburthe, Marc
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419634/
https://ncbi.nlm.nih.gov/pubmed/17885205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0361
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