Leukemia Inhibitory Factor Regulates Trophoblast Giant Cell Differentiation via Janus Kinase 1-Signal Transducer and Activator of Transcription 3-Suppressor of Cytokine Signaling 3 Pathway

Suppressor of cytokine signaling 3 (SOCS3) inhibits leukemia-inhibitory factor (LIF) signaling and acts as a negative regulator. Deletion of SOCS3 causes embryonic lethality because of placental failure, and genetic reduction of LIF or the LIF receptor (LIFR) in SOCS3-deficient mice rescues placenta...

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Bibliographic Details
Published in:Mol Endocrinol
Main Authors: Takahashi, Yutaka, Takahashi, Michiko, Carpino, Nick, Jou, Shiann-Tarng, Chao, Jyh-Rong, Tanaka, Satoshi, Shigeyoshi, Yasufumi, Parganas, Evan, Ihle, James N.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419438/
https://ncbi.nlm.nih.gov/pubmed/18451094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0058
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