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Specific CDK4/6 inhibition in breast cancer: a systematic review of current clinical evidence

BACKGROUND: Loss of cell cycle control is a hallmark of cancer, and aberrations in the cyclin-dependent kinase-retinoblastoma (CDK-Rb) pathway are common in breast cancer (BC). Consequently, inhibition of this pathway is an attractive therapeutic strategy. The present review addresses efficacy and t...

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Detalhes bibliográficos
Publicado no:ESMO Open
Main Authors: Polk, Anne, Kolmos, Ida Lykke, Kümler, Iben, Nielsen, Dorte Lisbeth
Formato: Artigo
Idioma:Inglês
Publicado em: ESMO Open 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419212/
https://ncbi.nlm.nih.gov/pubmed/28848657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2016-000093
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