A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Reprogramming has been shown to involve EMT–MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to hepatic lineage undergoes a sequential EMT–MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals that Acti...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Qiuhong, Hutchins, Andrew P., Chen, Yong, Li, Shengbiao, Shan, Yongli, Liao, Baojian, Zheng, Dejin, Shi, Xi, Li, Yinxiong, Chan, Wai-Yee, Pan, Guangjin, Wei, Shicheng, Shu, Xiaodong, Pei, Duanqing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418622/
https://ncbi.nlm.nih.gov/pubmed/28466868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15166
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