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Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial

OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This study assessed the efficacy and safety of tenapanor in patients with constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In this phase 2, double-blind stud...

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Detalhes bibliográficos
Publicado no:Am J Gastroenterol
Main Authors: Chey, William D, Lembo, Anthony J, Rosenbaum, David P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418559/
https://ncbi.nlm.nih.gov/pubmed/28244495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2017.41
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