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Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases
Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT(1B) receptor) and complex lesions (SERT, 5-HT(1B), 5-HT(2B) receptors) of the pulmonary vasculature together with right ventricular hypertrophy, ischemia and f...
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Publicado no: | Front Pharmacol |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Frontiers Media S.A.
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418348/ https://ncbi.nlm.nih.gov/pubmed/28529483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00240 |
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