Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation

Single sub-anesthetic doses of ketamine can exacerbate the symptoms of patients diagnosed with schizophrenia, yet similar ketamine treatments rapidly reduce depressive symptoms in major depression. Acute doses of the atypical antipsychotic drug clozapine have also been shown to counteract ketamine-i...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Rame, Marion, Caudal, Dorian, Schenker, Esther, Svenningsson, Per, Spedding, Michael, Jay, Thérèse M., Godsil, Bill P.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417651/
https://ncbi.nlm.nih.gov/pubmed/28472198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177036
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