Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation

Single sub-anesthetic doses of ketamine can exacerbate the symptoms of patients diagnosed with schizophrenia, yet similar ketamine treatments rapidly reduce depressive symptoms in major depression. Acute doses of the atypical antipsychotic drug clozapine have also been shown to counteract ketamine-i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rame, Marion, Caudal, Dorian, Schenker, Esther, Svenningsson, Per, Spedding, Michael, Jay, Thérèse M., Godsil, Bill P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417651/
https://ncbi.nlm.nih.gov/pubmed/28472198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177036
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