Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event. Thrombin generation (TG) is a global coagulation test and its...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Kremers, Romy M. W., Kleinegris, Marie-Claire, Ninivaggi, Marisa, de Laat, Bas, ten Cate, Hugo, Koek, Ger H., Wagenvoord, Rob J., Hemker, H. Coenraad
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417641/
https://ncbi.nlm.nih.gov/pubmed/28472132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177020
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