T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells

We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulation of this receptor with sucralose or saccharin indu...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Masubuchi, Yosuke, Nakagawa, Yuko, Medina, Johan, Nagasawa, Masahiro, Kojima, Itaru, Rasenick, Mark M., Inagaki, Takeshi, Shibata, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417608/
https://ncbi.nlm.nih.gov/pubmed/28472098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176841
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