The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain

Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that SH2-containing inositol 5′-phosphatase 2 (SHIP2), a...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Soeda, Yoshiyuki, Tsuneki, Hiroshi, Muranaka, Hayato, Mori, Norihiko, Hosoh, Shuji, Ichihara, Yoshinori, Kagawa, Syota, Wang, Xu, Toyooka, Naoki, Takamura, Yusaku, Uwano, Teruko, Nishijo, Hisao, Wada, Tsutomu, Sasaoka, Toshiyasu
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2010
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417391/
https://ncbi.nlm.nih.gov/pubmed/20829391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0163
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