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Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin

Dengue virus (DENV), which has four serotypes (DENV-1 to DENV-4), is the causative agent of the viral infection dengue. DENV nonstructural protein 3 (NS3) comprises a serine protease domain and an RNA helicase domain which has nucleotide triphosphatase activities that are essential for RNA replicati...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr D Struct Biol
Main Authors: Pan, Ankita, Saw, Wuan Geok, Subramanian Manimekalai, Malathy Sony, Grüber, Ardina, Joon, Shin, Matsui, Tsutomu, Weiss, Thomas M., Grüber, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417341/
https://ncbi.nlm.nih.gov/pubmed/28471365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317003849
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