Transforming Growth Factors α and β Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture Model

To gain insight into the cellular and molecular interactions mediating the desmoplastic reaction and aggressive malignancy of mass-forming intrahepatic cholangiocarcinoma (ICC), we modeled ICC desmoplasia and progression in vitro. A unique three-dimensional (3D) organotypic culture model was establi...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Manzanares, Miguel Á., Usui, Akihiro, Campbell, Deanna J., Dumur, Catherine I., Maldonado, Gabrielle T., Fausther, Michel, Dranoff, Jonathan A., Sirica, Alphonse E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417049/
https://ncbi.nlm.nih.gov/pubmed/28315313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.01.013
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