The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment

Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects in neuroplasticity, and the tissue-type plasminogen activator (tPA)/plasmin...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Jiang, H, Chen, S, Li, C, Lu, N, Yue, Y, Yin, Y, Zhang, Y, Zhi, X, Zhang, D, Yuan, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416686/
https://ncbi.nlm.nih.gov/pubmed/28375203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.43
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