The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP

[Image: see text] Biochemical and structural studies demonstrate that S100A1 is involved in a Ca(2+)-dependent interaction with the type 2α and type 2β regulatory subunits of protein kinase A (PKA) (RIIα and RIIβ) to activate holo-PKA. The interaction was specific for S100A1 because other calcium-bi...

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Publicado no:Biochemistry
Main Authors: Melville, Zephan, Hernández-Ochoa, Erick O., Pratt, Stephen J. P., Liu, Yewei, Pierce, Adam D., Wilder, Paul T., Adipietro, Kaylin A., Breysse, Daniel H., Varney, Kristen M., Schneider, Martin F., Weber, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415871/
https://ncbi.nlm.nih.gov/pubmed/28409622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00117
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