Chargement en cours...
CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome
Using a CRISPR/Cas9 system, we have reengineered a translational start site in the GATA1 gene in K562 cells. This mutation accounts largely for the onset of myeloid leukemia in Down syndrome (ML-DS). For this reengineering, we utilized CRISPR/Cas9 to generate mammalian cell lines that express trunca...
Enregistré dans:
| Publié dans: | Mol Ther Nucleic Acids |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Gene & Cell Therapy
2017
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5415552/ https://ncbi.nlm.nih.gov/pubmed/28624204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.04.009 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|