Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior

Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus are central components of systems regulating appetite and energy homeostasis. Here we report on the establishment of a mouse model in which the ribonuclease III ribonuclease Dicer-1 has been specifically deleted from POMC-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Endocrinol
Prif Awduron: Greenman, Yona, Kuperman, Yael, Drori, Yonat, Asa, Sylvia L., Navon, Inbal, Forkosh, Oren, Gil, Shosh, Stern, Naftali, Chen, Alon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2013
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415244/
https://ncbi.nlm.nih.gov/pubmed/23676213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1344
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