Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

Kaposi Sarcoma Herpesvirus (KSHV), a γ2-herpesvirus and class 1 carcinogen, is responsible for at least three human malignancies: Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD). Its major nuclear latency protein, LANA, is indispensable for the mainten...

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Udgivet i:PLoS Pathog
Main Authors: Mariggiò, Giuseppe, Koch, Sandra, Zhang, Guigen, Weidner-Glunde, Magdalena, Rückert, Jessica, Kati, Semra, Santag, Susann, Schulz, Thomas F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415203/
https://ncbi.nlm.nih.gov/pubmed/28430817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006335
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